This substitution may occur at any point either the Alpha or the Beta chains and remember we are focusing on the genotype AA, AS, SS, AC.
Genotype AA– At position 6 of both chains, the amino acid(which is the building block of proteins) is GLUTAMATE.
Genotype AS– At position 6 of one globin chain is GLUTAMATE and at position 6 of the second chain is VALINE.
Genotype SS– For this genotype, VALINE is present at both globin chains.
Genotype AC– GLUTAMATE is at position 6 of one globin chain and LYSINE at the position 6 of the second globni chain.
Hemoglobin are of different types which are Hemoglobin A, S, and C, Although Hemoglobin C is uncommon.
A person must possess a pair of these hemoglobin in their blood which are inherited from both parents. This paring may occur in the following ways AA, AS, AC, SC, SS or CC
Making it of utmost importance for couples to know their genotype at the early stage of the relationship before they get so into each other and begin to make statements like “In ba ke ba sai rijiya” – ‘If no be you na well i go love’. The emotions felt by the couple could affect their judgments resulting in the birth of sickle cell children if their GENOTYPES are not compatible, Hence subjecting themselves and their offspring’s to a lot of pain.
There are 4 major Genotypes – AA, AS, SS, and AC, AC genotype is rare while SS and SC are abnormal genotypes.
Now we know about the various genotypes, Let’s find out HOW PEOPLE GET THEIRS.
From your parents! If papa Ebuka has a genotype of AA and mama Ebuka has a genotype of type AS their kids genotype would be
AA+AS= AA, AS, AA, AS
Lets look at the possible outcomes of other Genetic combinations.
AA + AA = AA, AA, AA, AA
AA + SS = AS, AS, AS, AS
AA + AC = AA, AA, AA, AC
AS + AS = AA, AS, AS, SS
AS + SS = AS, SS, SS, SS
AS + AC = AA, AC, AS,SC
SS + SS = SS, SS, SS, SS
AC + SS = AS, AS, SS, SS
AC + AC = AA, AC, AC,CC
But if a couple with the genotype AA birth a child with the AS genotype then there must be one ‘Badosky’ who has been warming the wife’s bed in the absence of the husband. While taking the photos for the blog post alot of people never knew that AC, SC and CC genotypes EXISTED e.g LEEMA #wink# so lets shade more light on it. A person with AC can live a normal life, most times there are no symptoms but at times, there is JAUNDICE. But those with SS, SC and CC are affiliated with clinical signs, symptoms and syndromes.
Symptoms of Hemoglobin C
Most people do not have symptoms but at times, Jaundice may occur
Complication of Hemoglobin C
They may experience the following;
Splenomegoly (Big spleen)
Poor vision (Angloid streaks)
Cholelithiasis (Gall stone they may requir treatment)
Aplastic crisis (As a result of viral infection)
There is no treatment but Folic Acid supplementation should be taken to help with RBC production and improve symtoms of anaemia
AA: Normal properties
AS: No symptoms
AC: No symptoms
SS: Sickle Cell diseases
CC: as described above
SC: recurrent anaemia and pain crises,others may experience aseptic necrosis of the femur bone.
Please knowing your genotype is important, some people would say I DONT KNOW my genotype but am sure of not being a Sickle Cell Carrier because I hardly get sick but mind you some people with SS genotype may live normal lives until their 40s but before their crisis starts. People with AS or AC or SS or SC or CC can’t marry each other, If they want to avert SC or SS. they must marry a person with the AA genotype, if they do not want their offspring to have Sickle Cell Syndrome.
BMT is the only thing that could possibly change the genotype of a person. Bone Marrow Transplant Technology has shown to be the only PERMANENT core to SS, SC and CC. Although it is new and very very expensive and cannot be done in Africa and it has its risks.
Love is an emotion that alot of people would love to experience but before you start anything with anyone please endeavor to know the GENOTYPE of your partner to avoid kids with the SS genotype .Ask yourself this question….Being married to the love of your life and birthing kids with the SICKLE CELL DISEASE or the life with a healthy man and HEALTHY CHILDREN? THE CHOICE IS YOURSSS.!!
Thank you guys and a big shout to everyone who made this blog post a success, We say THANK YOU. XOXO!!!